CD73 is an enzyme involved in nucleotide metabolism, CD90 (Thy-1) is a glycoprotein associated with cell adhesion and signaling, and CD105 (endoglin) is a receptor component involved in cell signaling pathways. The ISCT minimal criteria include CD73/CD90/CD105 expression, plastic adherence and tri-lineage differentiation.
Marker expression is measured by flow cytometry, a laboratory technique that tags cells with fluorescent antibodies and counts how many cells in a sample carry a given marker. Ask for marker results and the sample tested, alongside the other ISCT criteria.
A marker panel result is one part of the ISCT framework, not the whole test, and does not by itself establish tri-lineage differentiation capacity. If a CD73/CD90/CD105 claim is attached to a product, confirm whether the other two ISCT criteria were assessed on the same sample.
A marker panel alone is not equivalent to a complete MSC characterization, so buyers should ask what else was tested alongside it.